Every season in the NFL produces performances that feel less like a single game and more like statistical outliers — explosive outings where quarterbacks pile up passing yards, running backs break off long scoring runs, and receivers turn routine targets into multi-touchdown afternoons. These are the kinds of games that separate good fantasy weeks from historic ones.
Stacker compiled a ranking of the best Buffalo Bills fantasy performances in the 2026 season using data from Stathead. The list includes the highest single-game fantasy scores by quarterbacks, running backs, wide receivers, and tight ends. Players are ranked based on standard fantasy scoring.
Best quarterback fantasy games
#5. Josh Allen, September 27, 2026
- Stats: 204 Passing Yards, 0 Passing TDs, 2 Interceptions, 22 Rushing Yards, 2 Rushing TDs
- Game: BUF vs LAC, 24-16 Win
- Fantasy points: 16.46
#4. Josh Allen, October 4, 2026
- Stats: 253 Passing Yards, 1 Passing TDs, 1 Interceptions, 1 Rushing TDs
- Game: BUF vs NWE, 26-29 Loss
- Fantasy points: 18.52
#3. Josh Allen, October 12, 2026
- Stats: 210 Passing Yards, 1 Passing TDs, 1 Interceptions, 121 Rushing Yards, 1 Rushing TDs
- Game: BUF vs LAR, 37-34 (OT) Win
- Fantasy points: 30.5
#2. Josh Allen, September 13, 2026
- Stats: 334 Passing Yards, 2 Passing TDs, 0 Interceptions, 23 Rushing Yards, 2 Rushing TDs
- Game: BUF vs HOU, 36-31 Win
- Fantasy points: 35.66
#1. Josh Allen, September 17, 2026
- Stats: 248 Passing Yards, 3 Passing TDs, 0 Interceptions, 69 Rushing Yards, 2 Rushing TDs
- Game: BUF vs DET, 41-31 Win
- Fantasy points: 40.82
Best running back fantasy games
#5. Ty Johnson, October 12, 2026
- Stats: 0 Rushing Yards, 0 Rushing TDs, 72 Receiving Yards
- Game: BUF vs LAR, 37-34 (OT) Win
- Fantasy points: 7.2
#4. James Cook, October 4, 2026
- Stats: 75 Rushing Yards, 1 Rushing TDs
- Game: BUF vs NWE, 26-29 Loss
- Fantasy points: 14.3
#3. James Cook, September 27, 2026
- Stats: 154 Rushing Yards, 1 Rushing TDs
- Game: BUF vs LAC, 24-16 Win
- Fantasy points: 19.4
#2. James Cook, September 17, 2026
- Stats: 135 Rushing Yards, 1 Rushing TDs
- Game: BUF vs DET, 41-31 Win
- Fantasy points: 19.9
#1. James Cook, October 12, 2026
- Stats: 111 Rushing Yards, 2 Rushing TDs
- Game: BUF vs LAR, 37-34 (OT) Win
- Fantasy points: 21.8
Best wide receiver fantasy games
#5. Khalil Shakir, October 12, 2026
- Stats: 80 Receiving Yards, 0 Receiving TDs, 3 Receptions, 3 Targets
- Game: BUF vs LAR, 37-34 (OT) Win
- Fantasy points: 8.0
#4. Josh Palmer, September 13, 2026
- Stats: 34 Receiving Yards, 1 Receiving TDs, 1 Receptions, 2 Targets
- Game: BUF vs HOU, 36-31 Win
- Fantasy points: 9.4
#3. Josh Palmer, September 17, 2026
- Stats: 43 Receiving Yards, 1 Receiving TDs, 1 Receptions, 3 Targets
- Game: BUF vs DET, 41-31 Win
- Fantasy points: 10.3
#2. D.J. Moore, September 13, 2026
- Stats: 100 Receiving Yards, 1 Receiving TDs, 5 Receptions, 8 Targets
- Game: BUF vs HOU, 36-31 Win
- Fantasy points: 16.0
#1. Keon Coleman, October 4, 2026
- Stats: 116 Receiving Yards, 1 Receiving TDs, 6 Receptions, 7 Targets
- Game: BUF vs NWE, 26-29 Loss
- Fantasy points: 17.6
Best tight end fantasy games
#5. Dalton Kincaid, September 27, 2026
- Stats: 38 Receiving Yards, 0 Receiving TDs, 2 Receptions, 3 Targets
- Game: BUF vs LAC, 24-16 Win
- Fantasy points: 1.8
#4. Dalton Kincaid, October 12, 2026
- Stats: 7 Receiving Yards, 0 Receiving TDs, 1 Receptions, 2 Targets
- Game: BUF vs LAR, 37-34 (OT) Win
- Fantasy points: 2.7
#3. Dawson Knox, September 17, 2026
- Stats: 5 Receiving Yards, 1 Receiving TDs, 2 Receptions, 2 Targets
- Game: BUF vs DET, 41-31 Win
- Fantasy points: 6.5
#2. Dalton Kincaid, September 13, 2026
- Stats: 130 Receiving Yards, 0 Receiving TDs, 5 Receptions, 6 Targets
- Game: BUF vs HOU, 36-31 Win
- Fantasy points: 13.0
#1. Dalton Kincaid, September 17, 2026
- Stats: 95 Receiving Yards, 1 Receiving TDs, 7 Receptions, 8 Targets
- Game: BUF vs DET, 41-31 Win
- Fantasy points: 15.5
